Effect of calcium bodesilate (doxium) on circulatory disorders of the retina with special emphasis on diabetic retinopathy.

doi:10.1159/000307250

Paper

Effect of calcium bodesilate (doxium) on circulatory disorders of the retina with special emphasis on diabetic retinopathy.

Published 1975 · B. Nemeth, J. Hudomel, Á. Farkas

Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde

UNKNOWN SJR score

6

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Abstract

The authors examined the effect of calcium dobesilate (Doxium ¿) on 85 subjects with diabetic retinopathy, occlusion of the central vein of the retina and other retinopathies of vascular origin. Capillary resistance measured on the skin and conjunctiva showed, as compared with 100 healthy subjects, a significant decrease. The efficacy of long-term treatment with Doxium was highly significant in restoring CR to normal. Visual acuity improved in 45.8% of simple DR cases, and became stabilized in 27.5% of cases with malignant DR. Hyperpermeability of retinal vessels decreased in 60% of simple DR cases. It is pointed out that glaucoma did not develop in cases of venous occlusion and the diagnostic value of capillary resistance measurement in diabetes. As a highly effective vasoprotective drug, Doxium¿ is the treatment of choice in all retinopathies of vascular etiology.

Non-RCT

Study Snapshot

Doxium is a highly effective vasoprotective drug for treating retinopathies of vascular origin, improving visual acuity and reducing retinal vessel hyperpermeability in patients.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Effect of calcium bodesilate (doxium) on circulatory disorders of the retina with special emphasis on diabetic retinopathy.

References

Citations

Selective electrochemical sensing of calcium dobesilate based on the nano-Pd/CNTs modified pyrolytic graphite electrode.

Nano-Pd/CNTs modified pyrolytic graphite electrodes provide a selective and sensitive electrochemical sensor for calcium dobesilate in pharmaceutical capsules, with good stability, sensitivity, and reproducibility.

Inhibition of choroidal angiogenesis by calcium dobesilate in normal Wistar and diabetic GK rats.

Calcium dobesilate inhibits choroidal angiogenesis in both vitro and ex vivo, potentially contributing to its therapeutic benefit in diabetic retinopathy.

Reduction of retinal albumin leakage by the antioxidant calcium dobesilate in streptozotocin-diabetic rats.

Calcium dobesilate significantly reduces retinal albumin leakage, CML-AGE contents, and VEGF overexpression in diabetic rats, suggesting its potential as an antioxidant treatment for diabetic retinopathy.

Platelet function and prostaglandins in patients with peripheral vascular disease treated with calcium dobesilate.

Calcium dobesilate improves platelet function and prostaglandin synthesis in peripheral vascular disease patients, potentially explaining its beneficial clinical effect.

The effect of calcium dobesilate on nonproliferative diabetic retinopathy: a controlled study.

Calcium dobesilate showed no beneficial effect on nonproliferative diabetic retinopathy in a controlled study.