Carbopol thickened nanoemulsions of chemotherapeutics to treat DMBA-induced breast cancer
Vineeta Meena, R. Mathur, Azka Gull
Jul 5, 2022
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Journal
International journal of health sciences
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Semantic Scholar
Key Takeaway Key Takeaway: MTO-NE-Gel and 4-MU-NE-Gel show potential in reducing tumor weight and volume, improving tissue anatomical features, and decreasing tumor marker CA15-3 in DMBA-induced breast cancer.
Abstract
Breast cancer is the most frequent invasive malignancy in women globally. The goal of this study was to prepare mitoxantrone and 4-methyl umbelliferone nanoemulsions followed by hydrogel preparation viz. MTO-NE-Gel and 4-MU-NE-Gel and characterized for various parameters like visual assessment, pH, rheology, ex vivo studies, and in vivo studies in 7,12-dimethylbenz(a)anthracene-induced breast cancer in swiss albino mice. The pH, viscosity, and spreadability were found to be 5.62±0.05, 13107 cP ±658, and 5.3 g.cm/s ±0.28 for 4-MU-NE-Gel and 5.75±0.03, 13025 cP ±705, and 4.06 g.cm/s ±0.45 for MTO-NE-Gel. The percent cumulative amount of drug permeated for 4-MU suspension, MTO Solution,4-MU-NE-Gel, and MTO-NE-Gel were found to be 51.26% ±5.22, 15.54% ±3.91, 89.093% ± 6.8, and 97.242%±4.51 respectively after 8 h which was significantly higher in hydrogel formulations. The outcome of pharmacodynamic studies reveals a significant reduction in tumor weight and tumor volume for MTO-NE-Gel and 4-MU-NE-Gel treated mice as compared to MTO-Gel and 4-MU-sus-Gel. Histopathological evaluation of mammary tumors indicates improvement in the tissue anatomical features and a significant decreasing trend in levels of tumor marker CA15-3 was also observed. Based on the promising results of this investigation,,,