R. Ricciolini, M. Scalibastri, A. Sciarroni
Journal name not available for this finding
The carnitine system may be defined as a family of different short and long-chain acyltransferases, translocases, and their related substrates, whose common denominator is L-carnitine. The carnitine system is best known for the role played in mitochondrial metabolism, though the presence of carnitine-dependent short and long-chain acyltransferases in extra-mitochondrial compartments raises a number of intringuing question about their role. We have recently proposed that carnitine palmitoyltransferase (CPT) may be important in the pathway of phospholipid and triglyceride fatty acid turnover in neurons. The CPT action is accomplished by modulating the size and composition of the acyl-CoA pool between the activation step of the fatty acid and its transfer into complex lipids. In addition, studies on the metabolic fate of the acetate moiety of acetyl-L-carnitine revealed that the lipogenic acetyl-CoA pools present in different cellular compartments of rat brain are not necessary homogeneous. Taken together, these data suggest that the carnitine system may influence key regulatory points of lipid biosynthetic pathways.