Cell Life versus cell longevity: the mysteries surrounding the NAD+ precursor nicotinamide.

doi:10.2174/092986706776361058

Paper

Cell Life versus cell longevity: the mysteries surrounding the NAD+ precursor nicotinamide.

Published Mar 31, 2006 · Faqi Li, Zhao Zhong （兆忠） Chong （种）, K. Maiese

Current medicinal chemistry

Q1 SJR score

123

Citations

2

Influential Citations

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Abstract

Nicotinamide, the amide form of niacin (vitamin B(3)), is the precursor for the coenzyme beta-nicotinamide adenine dinucleotide (NAD(+)) and plays a significant role during the enhancement of cell survival as well as cell longevity. Yet, these abilities of nicotinamide appear to be diametrically opposed. Here we describe the development of nicotinamide as a novel agent that is critical for modulating cellular metabolism, plasticity, longevity, and inflammatory microglial function as well as for influencing cellular life span. The capacity of nicotinamide to govern not only intrinsic cellular integrity, but also extrinsic cellular inflammation rests with the modulation of a host of cellular targets that involve mitochondrial membrane potential, poly(ADP-ribose) polymerase, protein kinase B (Akt), Forkhead transcription factors, Bad, caspases, and microglial activation. Further knowledge acquired in regards to the ability of nicotinamide to foster cellular survival and regulate cellular lifespan should significantly promote the development of therapies against a host of disorders, such as aging, Alzheimer's disease, diabetes, cerebral ischemia, Parkinson's disease, and cancer.

Highly Cited

Study Snapshot

Nicotinamide plays a crucial role in cellular metabolism, plasticity, longevity, and inflammatory microglial function, potentially promoting therapies against disorders like aging, Alzheimer's, and cancer.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Cell Life versus cell longevity: the mysteries surrounding the NAD+ precursor nicotinamide.

References

Citations

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