Cs2CO3-mediated domino benzalation reaction with a variety of 2-aryl-3-nitro-2 H-chromenes and 4-benzylidene-2-phenyloxazol-5(4 H)-ones has been realized. The reaction proceeds smoothly with a broad substrate scope, thus providing a variety of substituted ( Z)-4-(( Z)-benzylidene)chroman-3-one oximes in moderate to high yields, which were easily transformed into biologically important 4 H-chromeno[3,4- c]isoxazoles.

Cs2CO3-mediated domino benzalation effectively produces various substituted (Z)-4-((Z)-benzylidene)chroman-3-one oximes in moderate to high yields, which can easily be transformed into biologically important 4 H-chromeno[3,4-c]

Cesium-Carbonate-Mediated Benzalation of Substituted 2-Aryl-3-nitro-2 H-chromenes with Substituted 4-Benzylidene-2-phenyloxazol-5(4 H)-ones.

Key Takeaway: Cs2CO3-mediated domino benzalation effectively produces various substituted (Z)-4-((Z)-benzylidene)chroman-3-one oximes in moderate to high yields, which can easily be transformed into biologically important 4 H-chromeno[3,4-c]