Chemical Synthesis, Mechanism of Action and Anticancer Potential of Medicinally Important Thiazolidin-2,4-dione Derivatives: A Review.

doi:10.2174/1389557519666190513093618

Paper

Chemical Synthesis, Mechanism of Action and Anticancer Potential of Medicinally Important Thiazolidin-2,4-dione Derivatives: A Review.

Published 2019 · H. Kumar, A. Deep, R. K. Marwaha

Mini reviews in medicinal chemistry

Q2 SJR score

7

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0

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Abstract

Thiazolidin-2,4-dione (TZD) possessing an active methylene constitute an important chemical class of compounds for the development of new drugs. So, many scholars have synthesized these derivatives as target molecules and evaluated their biological potential. Currently, some of the TZDs are synthesized to treat human cancers stating high levels of PPARγ because it is expected that activation of PPARγ arbitrates their anticancer activity because PPARγ ligands have recently been established to affect differentiation, cell proliferation and apoptosis of different cell types. In the present review, synthesis of various derivatives of thiazolidine-2,4-diones, their mechanism of action and anticancer activity has been highlighted.

Study Snapshot

Thiazolidin-2,4-dione derivatives show potential anticancer activity by activating PPAR, affecting differentiation, cell proliferation, and apoptosis in various cell types.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Chemical Synthesis, Mechanism of Action and Anticancer Potential of Medicinally Important Thiazolidin-2,4-dione Derivatives: A Review.

References

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Citations

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