Two chiral cyclohexanones were linked to polystyrene resin. The polymer-bound auxiliaries were subjected to a sequence of four reactions, the last of which cleaves the desired α-chiral carbonyl compound off the resin, concurrently regenerating the resin-bound auxiliary in its original form. The resin can then be reused.‘

This study demonstrates a solid-phase synthesis method for chiral -carbonyls using chiral cyclohexanones linked to polystyrene, enabling the reuse of the resin-bound auxiliary and reducing waste.

Paper

A Chiral Cyclohexanone Linked to Polystyrene for Solid-Phase Synthesis of Chiral α-Carbonyls

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