Effect of citrate, glutathione and picolinate on zinc transport by brush border membrane vesicles from rat intestine.

doi:10.1093/JN/113.8.1653

Paper

Effect of citrate, glutathione and picolinate on zinc transport by brush border membrane vesicles from rat intestine.

Published Aug 1, 1983 · M. Ménard, R. Cousins

The Journal of nutrition

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Abstract

Brush border membrane vesicles were used to evaluate the influence of a variety of potential zinc-binding ligands on zinc transport in the rat. Citrate, glutathione (reduced) and picolinate were added to the extravesicular incubation medium at 0.38 mM. Transport was evaluated for up to 60 minutes at an extravesicular zinc concentration of 0.2 mM. Citrate depressed zinc transport at each time point checked. Picolinate depressed transport after 5 minutes of incubation. Glutathione slightly enhanced transport after 60 minutes of incubation. Neither citrate, glutathione nor picolinate had an influence on D-glucose transport. These results suggest that the compounds evaluated do not enhance zinc transport across the brush border surface of the small intestine of the rat.

Study Snapshot

Key takeawayCitrate, glutathione, and picolinate do not enhance zinc transport across the brush border surface of the small intestine of the rat.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Effect of citrate, glutathione and picolinate on zinc transport by brush border membrane vesicles from rat intestine.

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