Nortriptyline (Allegron, Aventyl) is the demethylated metabolite of amitriptyline. Preliminary trials by Bennett (1962), Oltman et al. (1963) and Leahy et al. (1964) indicated that it might be an effective anti-depressant. Forrest et al. (1964) found that it compared favourably with amitriptyline, a widely used anti-depressant of established efficacy. This investigation also compares nortriptyline with amitriptyline.

Nortriptyline shows potential as an effective anti-depressant, compared to amitriptyline, with both showing promising results in clinical trials.

Paper

A Comparison of Nortriptyline and Amitriptyline in Depression

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