Paper
The anti‐migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel
Published Jun 16, 2017 · S. Benemei, Francesco De Logu, Simone Li Puma
British Journal of Pharmacology
Q1 SJR score
46
Citations
2
Influential Citations
Abstract
The mechanism of the anti‐migraine action of extracts of butterbur [Petasites hybridus (L.) Gaertn.] is unknown. Here, we investigated the ability of isopetasin, a major constituent of these extracts, to specifically target TRPA1 channel and to affect functional responses relevant to migraine.
In Vitro Study
Rigorous JournalStudy Snapshot
Isopetasin, a component of butterbur extracts, effectively reduces migraine symptoms by targeting the TRPA1 cation channel and affecting peptidergic nociceptors.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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