Computational and Genetic Reduction of a Cell Cycle to Its Simplest, Primordial Components

doi:10.1371/journal.pbio.1001749

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Computational and Genetic Reduction of a Cell Cycle to Its Simplest, Primordial Components

S. Murray, G. Panis, Coralie Fumeaux

Dec 1, 2013

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PLoS Biology

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Key Takeaway

Key Takeaway: The bacterium Caulobacter crescentus shows redundancy in cell cycle regulation through the dispensability of key transcription factors GcrA and methyltransferase CcrM, which together form a genetic module.

Abstract

Mathematical modelling and genetics in the bacterium Caulobacter crescentus identified redundancy in asymmetric cell cycle regulation through the dispensability of key transcription factor GcrA and methyltransferase CcrM, which together form a genetic module.

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