Conserved tyrosines in the alpha subunit of the nicotinic acetylcholine receptor stabilize quaternary ammonium groups of agonists and curariform antagonists.

doi:10.1016/s0021-9258(17)37041-2

Paper

Conserved tyrosines in the alpha subunit of the nicotinic acetylcholine receptor stabilize quaternary ammonium groups of agonists and curariform antagonists.

Published Mar 25, 1994 · S. Sine, Polly A. Quiram, Frank Papanikolaou

The Journal of biological chemistry

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126

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7

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Abstract

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In Vitro Study

Highly Cited

Study Snapshot

All three conserved tyrosines in the nicotinic acetylcholine receptor alpha subunit contribute to binding of agonists and antagonists, with Tyr-93 and Tyr-190 having essential aromatic hydroxyls and Tyr-198 having essential side chain aromaticity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Conserved tyrosines in the alpha subunit of the nicotinic acetylcholine receptor stabilize quaternary ammonium groups of agonists and curariform antagonists.

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