Control factors affecting gluconeogenesis in perfused rat liver. Effects of 4-pentenoic acid.

doi:10.1016/s0021-9258(18)63046-7

Paper

Control factors affecting gluconeogenesis in perfused rat liver. Effects of 4-pentenoic acid.

Published Jun 25, 1970 · J. Williamson, S. Rostand, M. Peterson

The Journal of biological chemistry

Q1 SJR score

47

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1

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Abstract

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In Vitro Study

Study Snapshot

4-pentenoic acid metabolism in perfused rat livers leads to inhibitions of fatty acid oxidation, pyruvate oxidation, gluconeogenesis, and the citric acid cycle, with severity depending on duration and concentration.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Control factors affecting gluconeogenesis in perfused rat liver. Effects of 4-pentenoic acid.

References

Citations

Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia.

Ketogenesis plays a critical role in preventing diet-induced fatty liver injury and hyperglycemia, suggesting it may modulate fatty liver disease.

A computer model of gluconeogenesis and lipid metabolism in the perfused liver.

The developed mathematical model accurately predicts gluconeogenesis and lipid metabolism in the perfused rat liver, providing a useful tool for analyzing complex relationships between carbohydrate and fat metabolism.

Dietary fat mediates hyperglycemia and the glucogenic response to increased protein consumption in an insect, Manduca sexta L.

Dietary fat in Manduca sexta larvae increases gluconeogenic flux and blood trehalose levels, affecting blood sugar regulation and food preferences.

Stimulation by carnitine of branched-chain α-keto acid dehydrogenase in intact heart mitochondria of rats

Carnitine stimulates branched-chain keto acid oxidation in rat heart mitochondria by altering intra-mitochondrial levels of branched-chain acyl-CoA esters and/or free CoA, primarily through the involvement of carnitine acyl transferase II

Effects of pentanoate, 4-pentenoate, 3-hydroxybutyrate and insulin on the tissue-levels of long-chain acyl CoA and acylcarnitine in the oxygenated and hypoxic rat atria.

Insulin improves hypoxic atria performance by increasing LCCoA levels and decreasing LCCa levels, suggesting that LCCoA may not be involved in the harmful effects of fatty acid oxidation.