Corneal anesthesia induced by soaps and surfactants, lack of correlation in rabbits and humans.
L. Harris, Y. Kahanowicz, M. Shimmyo
1975
Citations
7
Citations
Quality indicators
Journal
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde
Full text
Semantic Scholar
Key Takeaway Key Takeaway: Soaps and shampoos can induce corneal anesthesia in rabbits, but their effects on humans are unclear, suggesting their use in rabbits may not accurately reflect human corneas.
Abstract
Five commonly marketed bath and facial soaps and four commercially available hair shampoos were studied for their anesthetic effect on human and rabbit corneas. These compounds all produced anesthesia comparable to that induced by tetracaine hydrochloride 0.5 percent but lasting several hours longer in rabbits. None of the soaps or shampoos produced corneal anesthesia in humans. Studies of corneal anesthesia in rabbits may not be extrapolated to the human eye.
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