Design, synthesis and biological evaluation of substituted aminopyridazin-3(2H)-ones as G0/G1-phase arresting agents with apoptosis-inducing activities.

doi:10.1016/j.ejmech.2017.09.077

Paper

DOI: 10.1016/j.ejmech.2017.09.077

Design, synthesis and biological evaluation of substituted aminopyridazin-3(2H)-ones as G0/G1-phase arresting agents with apoptosis-inducing activities.

Published Dec 1, 2017 · Bing-Chen Ge, Hongfang Feng, Yufang Cheng

European journal of medicinal chemistry

Q2 SJR score

Citations

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

Substituted aminopyridazin-3(2H)-one derivatives show potential as G0/G1-phase arresting agents with apoptosis-inducing activities in human cancer cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Full text analysis coming soon...

References

DOI: 10.1016/j.bmc.2015.10.033

Catecholic amides as potential selective phosphodiesterase 4D inhibitors: Design, synthesis, pharmacological evaluation and structure-activity relationships.

Catechol-based amides show potential as potent and selective phosphodiesterase 4D inhibitors, with compound 8g showing 10-fold selectivity over PDE4B subtypes and over 1000-fold selectivity against other PDE family members.

2015·15citations·Zhong-Zhen Zhou et al.·Bioorganic & medicinal chemistry

Bioorganic & medicinal chemistry

DOI: 10.1016/j.ejmech.2015.03.041

Enhancing the cellular anti-proliferation activity of pyridazinones as c-met inhibitors using docking analysis.

The quinoline-pyridazinone 8a, designed with hydrophobic and hydrophilic properties, effectively inhibits c-Met enzyme activity and EBC-1 cell proliferation.

2015·30citations·Weiqiang Xing et al.·European journal of medicinal chemistry

European journal of medicinal chemistry

DOI: 10.1016/j.ejmech.2014.11.030

Synthesis and anticancer activities of 3-arylflavone-8-acetic acid derivatives.

3-arylflavone-8-acetic acid derivatives show moderate direct cytotoxicities against cancer cells, with some showing higher indirect cytotoxicities against A549 lung adenocarcinoma cells than DMXAA.

2015·16citations·G. Yan et al.·European journal of medicinal chemistry

European journal of medicinal chemistry

DOI: 10.1016/j.ejmech.2014.06.068

Design, synthesis and structure-activity relationships of novel 4-phenoxyquinoline derivatives containing pyridazinone moiety as potential antitumor agents.

Novel 4-phenoxyquinoline derivatives containing pyridazinone moiety show promising antitumor activity, with compound 15a showing 1.5-2.3-fold more potent cytotoxicity against cancer cell lines than foretinib.

2014·31citations·Shunguang Zhou et al.·European journal of medicinal chemistry

European journal of medicinal chemistry

DOI: 10.1021/jm500764v

Design, Synthesis, and Biological Evaluation of Stable Colchicine Binding Site Tubulin Inhibitors as Potential Anticancer Agents

New tubulin inhibitors targeting the colchicine binding site show enhanced antitumor activity and improved metabolic stability, offering potential as anticancer agents.

2014·82citations·Yan Lu et al.·Journal of Medicinal Chemistry

Journal of Medicinal Chemistry

Citations

DOI: 10.1016/j.bioorg.2024.107411

Utility of sulfachloropyridazine in the synthesis of novel anticancer agents as antiangiogenic and apoptotic inducers.

Sulfachloropyridazine hybrids show potential as antiangiogenic and apoptotic agents, with potential synergistic effects with -radiation.

2024·4citations·Sally S Zahran et al.·Bioorganic chemistry

Bioorganic chemistry

DOI: 10.22037/ijpr.2021.114371.14835

Phenanthrotriazine Derivatives Containing Arylidine Hydrazone Moieties as Novel Potential c-Met Inhibitors with Anticancer Effect

Phenanthrene 1,2,4-triazines show promising antiproliferative activity against cancer cells, with potential c-Met inhibitory capacity.

2021·4citations·Najmeh Edraki et al.·Iranian Journal of Pharmaceutical Research : IJPR

Iranian Journal of Pharmaceutical Research : IJPR

DOI: 10.1016/j.ejmech.2020.112946

Pyridazine as a privileged structure: An updated review on anticancer activity of pyridazine containing bioactive molecules.

Pyridazine derivatives show potential as active and less toxic anticancer agents due to their favorable physicochemical properties and antitumor potential.

2020·51citations·Zhangxu He et al.·European journal of medicinal chemistry

European journal of medicinal chemistry

DOI: 10.1021/acsmedchemlett.0c00278

Synthesis, Biological Evaluation, and Molecular Docking of Arylpyridines as Antiproliferative Agent Targeting Tubulin.

Arylpyridine derivatives with benzo[d]imidazole and benzo[d]oxazole side chains show broad-spectrum antitumor activities and show potential as new cancer drugs.

2020·13citations·JiaPeng He et al.·ACS medicinal chemistry letters

ACS medicinal chemistry letters

DOI: 10.1021/acsomega.9b02543

Discovery of Dihydropyrrol-2-ones as Novel G0/G1-Phase Arresting Agents Inducing Apoptosis

Dihydropyrrol-2-ones (5a, 5q, and 5s) show potential as new anticancer agents by inducing cell apoptosis by increasing/decreasing p53 and p21/cyclin D1 levels.

2019·14citations·Danni Yang et al.·ACS Omega

ACS Omega

DOI: 10.1016/J.ICA.2019.04.007

Copper (I) complexes based on novel N, N′-disubstituted thiocarbamides: Synthesis, spectroscopic, in vitro cytotoxicity, DNA damage and G0/G1 cell cycle arrest studies

Copper (I) complexes based on novel N, N′-disubstituted thiocarbamides show stronger inhibitory properties than ligands, exhibiting DNA damage and apoptosis in human cancer cell lines.

2019·6citations·S. Pandey et al.·Inorganica Chimica Acta

Inorganica Chimica Acta

DOI: 10.1016/J.MOLSTRUC.2019.03.057

Synthesis, characterization, Hirshfeld surface, cytotoxicity, DNA damage and cell cycle arrest studies of N, N-diphenyl-N'-(biphenyl-4-carbonyl/4-chlorobenzoyl) thiocarbamides

N, N-diphenyl-N'-(biphenyl-4-carbonyl/4-chlorobenzoyl) thiocarbamides show promising activity against cervical and ovarian cancer cells, with DNA damage and cell cycle arrest supporting their anti-cancer properties.

2019·10citations·S. Pandey et al.·Journal of Molecular Structure

Journal of Molecular Structure

DOI: 10.1016/j.ejmech.2019.02.026

Discovery of arylbenzylamines as PDE4 inhibitors with potential neuroprotective effect.

Arylbenzylamine derivatives with improved oral bioavailability show potential as PDE4 inhibitors for Parkinson's disease treatment, with greater neuroprotective effects than rolipram.

2019·23citations·Lv Tang et al.·European journal of medicinal chemistry

European journal of medicinal chemistry

DOI: 10.1111/cbdd.13438

Discovery of 2‐(3,4‐dialkoxyphenyl)‐2‐(substituted pyridazin‐3‐yl)acetonitriles as phosphodiesterase 4 inhibitors with anti‐neuroinflammation potential based on three‐dimensional quantitative structure–activity relationship study

Compound 16a shows potential anti-neuroinflammation activity in BV-2 cells, showing good inhibitory activities against PDE4B1 and PDE4D7 and a "V-shaped" conformation in the PDE4 catalytic domain.

2018·8citations·Chang Huang et al.·Chemical Biology & Drug Design

Chemical Biology & Drug Design