Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl)-6-pyrrolidinylquinolin-4-one as a potent anticancer lead.
Published Sep 15, 2013 · Yung-Yi Cheng, Chin-Yu Liu, Meng-Tung Tsai
Bioorganic & medicinal chemistry letters
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7
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Abstract
Abstract removed due to Elsevier request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Study Snapshot
Key takeawayCompound 6h shows strong inhibitory activity against various human cancer cell lines, particularly non-small cell lung cancer NCI-H522, with a mechanism of action similar to vincristine.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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