Design, synthesis, and optical resolution of a novel non-natural chiral auxiliary, 1-(2,5-dimethoxyphenyl)ethylamine. Application to diastereoselective alkylation of aldimines

doi:10.1016/S0040-4020(99)00307-5

Paper

DOI: 10.1016/S0040-4020(99)00307-5

Design, synthesis, and optical resolution of a novel non-natural chiral auxiliary, 1-(2,5-dimethoxyphenyl)ethylamine. Application to diastereoselective alkylation of aldimines

Published May 21, 1999 · Takehiro Kohara, Y. Hashimoto, K. Saigo

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Abstract

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Study Snapshot

1-(2,5-dimethoxyphenyl)ethylamine is an effective chiral auxiliary for diastereoselective alkylation of aldimines with alkylmetals, enabling amino-transfer and amino-transfer reactions.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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