Detection of recombinant Spike protein in the blood of individuals vaccinated against SARS‐CoV‐2: Possible molecular mechanisms

doi:10.1002/prca.202300048

Paper

Detection of recombinant Spike protein in the blood of individuals vaccinated against SARS‐CoV‐2: Possible molecular mechanisms

Published Aug 31, 2023 · Carlo Brogna, S. Cristoni, Giuliano Marino

PROTEOMICS – Clinical Applications

UNKNOWN SJR score

18

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1

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Abstract

The SARS‐CoV‐2 pandemic prompted the development and use of next‐generation vaccines. Among these, mRNA‐based vaccines consist of injectable solutions of mRNA encoding for a recombinant Spike, which is distinguishable from the wild‐type protein due to specific amino acid variations introduced to maintain the protein in a prefused state. This work presents a proteomic approach to reveal the presence of recombinant Spike protein in vaccinated subjects regardless of antibody titer.

Study Snapshot

Key takeawayRecombinant Spike protein is present in the blood of individuals vaccinated against SARS-CoV-2, regardless of antibody titer, suggesting potential molecular mechanisms in mRNA-based vaccines.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Detection of recombinant Spike protein in the blood of individuals vaccinated against SARS‐CoV‐2: Possible molecular mechanisms

References

Citations

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