Determination of the antioxidative activity of substituted 5-aminopyrimidines

doi:10.3109/10715762.2011.638292

Paper

Determination of the antioxidative activity of substituted 5-aminopyrimidines

Published Jan 1, 2012 · E. Procházková, P. Jansa, M. Dračínský

Free Radical Research

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Abstract

The aminopyrimidine structural motif can be found in diverse biologically active compounds. This study aimed to describe the antioxidant activity of a series of di- and tri-substituted 5-aminopyrimidines using in vitro (TEAC, LPO) and cell-based assays. 2,4,6-trisubstituted 5-aminopyrimidines displayed the highest activity in the TEAC and LPO assays whereas compounds with protected 5-aminogroup were active in the cellular assay. This is most likely because of their better membrane permeability and intracellular metabolic activation. In summary, we have identified the antioxidant activity of a series of substituted 5-aminopyrimidines and their potential prodrugs which may have implications in the treatment of oxidative stress-related diseases.

In Vitro Study

Study Snapshot

Substituted 5-aminopyrimidines show antioxidant activity, potentially benefiting oxidative stress-related diseases.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Determination of the antioxidative activity of substituted 5-aminopyrimidines

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