Differential behaviour of cationic triphenylamine derivatives in fixed and living cells: triggering and imaging cell death.

doi:10.1039/c5cc05970d

Paper

Differential behaviour of cationic triphenylamine derivatives in fixed and living cells: triggering and imaging cell death.

Published Sep 24, 2015 · R. Chennoufi, H. Bougherara, N. Gagey-Eilstein

Chemical communications

Q1 SJR score

24

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0

Influential Citations

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Abstract

Triphenylamines are on/off fluorescent DNA minor groove binders, allowing nuclear staining of fixed cells. By contrast, they accumulate in the cytoplasm of living cells and efficiently trigger cell apoptosis upon prolonged visible light irradiation. This process occurs concomitantly with their subcellular re-localization to the nucleus, enabling fluorescence imaging of apoptosis.

Study Snapshot

Triphenylamines effectively trigger cell apoptosis in living cells, enabling fluorescence imaging of apoptosis, while also serving as fluorescent DNA minor groove binders in fixed cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Differential behaviour of cationic triphenylamine derivatives in fixed and living cells: triggering and imaging cell death.

References

Beyond Glycolysis: GAPDHs Are Multi-functional Enzymes Involved in Regulation of ROS, Autophagy, and Plant Immune Responses

Plant GAPDHs play diverse roles in regulating ROS, autophagy, and plant immune responses, beyond their role in glycolysis.

Molecular Imaging of Apoptosis: From Micro to Macro

Molecular imaging of apoptosis has advanced, enabling improved diagnosis, patient management, and development of new therapies in various human conditions.

Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages

Anoctamin 6 plays a crucial role in macrophage innate immunity by supporting bacterial phagocytic and killing processes through its activation by P2X7 receptors.

Tunable cytotoxicity of rhodamine 6G via anion variations.

Rhodamine 6G-based organic salts with varying counteranions can be used as chemotherapeutic agents with low toxicity to normal cells and high toxicity to cancer cells, offering a promising approach for cancer treatment.

DNA switches on the two-photon efficiency of an ultrabright triphenylamine fluorescent probe specific of AT regions.

TP-2Bzim is a new ultrabright fluorescent DNA probe with improved affinity and fluorescence quantum yield, enabling submicromolar concentration imaging and ultrabright foci visualization in AT-rich chromatin.

Citations

Mitochondria/lysosome dual-organelle labelling esterase probe for monitoring cell viability and evaluating lung cancer drug efficiency.

The TMLE-2 probe effectively monitors cell viability and evaluates lung cancer drug efficiency in real-time, aiding in cancer therapy and biomedical advancements.

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6BrCaQ-TPP conjugates show excellent anti-proliferative activity in various human cancer cells, with the best lead compound 6BrCaQ-C10-TPP targeting the TRAP-1 mitochondrial Hsp90 machinery.

Fluorogenic Protein Probes with Red and Near-Infrared Emission for Genetically Targeted Imaging.

Our red and near-infrared protein fluorophores show promising potential for high-contrast, no-wash imaging of proteins like nucleus and actin in living cells.

Light-Triggered Trafficking to the Cell Nucleus of a Cationic Polyamidoamine Functionalized with Ruthenium Complexes

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Fluorogenic Protein Probes with Red or Near-Infrared Emission for Genetically Targeted Live-Cell Imaging

Fluorogenic protein probes with red or near-infrared emission can be used for genetically targeted live-cell imaging in wash-free conditions.