Dihydrosanguinarine suppresses pancreatic cancer cells via regulation of mut-p53/WT-p53 and the Ras/Raf/Mek/Erk pathway.

doi:10.1016/j.phymed.2019.152895

Paper

DOI: 10.1016/j.phymed.2019.152895

Dihydrosanguinarine suppresses pancreatic cancer cells via regulation of mut-p53/WT-p53 and the Ras/Raf/Mek/Erk pathway.

Published Jun 1, 2019 · Sizhi Wu, Huachong Xu, Xian-lin Wu

Phytomedicine : international journal of phytotherapy and phytopharmacology

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Rigorous Journal

Study Snapshot

Dihydrosanguinarine inhibits pancreatic cancer cell proliferation, migration, and invasion by regulating mut-p53/-Ras and WT-p53/-Ras proteins, restoring the balance between Ras and p53 proteins.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

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Critical role of H2O2 in mediating sanguinarine-induced apoptosis in prostate cancer cells via facilitating ceramide generation, ERK1/2 phosphorylation, and Par-4 cleavage.

Sanguinarine induces apoptosis in prostate cancer cells by promoting ceramide generation, ERK1/2 phosphorylation, and Par-4 cleavage, potentially offering a nontoxic and effective treatment option.

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Fluctuations in p53 Signaling Allow Escape from Cell-Cycle Arrest.

Fluctuations in p53 signaling can trigger cells to escape from long-term cell-cycle arrest, resulting in large phenotypic changes.

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KRAS targeting antibody synergizes anti-cancer activity of gemcitabine against pancreatic cancer.

RT11-i antibody synergistically increases the antitumor activity of gemcitabine against pancreatic cancer by inhibiting RAS downstream signaling, suggesting potential as a combination treatment option for KRAS mutation pancreatic cancer patients.

2018·38citations·Y. Kang et al.·Cancer letters

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Mutant p53 prevents GAPDH nuclear translocation in pancreatic cancer cells favoring glycolysis and 2-deoxyglucose sensitivity.

Mutant p53 in pancreatic cancer cells supports glycolysis and 2-deoxyglucose sensitivity, suggesting a potential personalized therapeutic approach for cancers with mutant TP53 gene.

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Simultaneous Inhibition of MEK and Hh Signaling Reduces Pancreatic Cancer Metastasis

Combining hedgehog and MEK signaling inhibitors reduces pancreatic cancer metastasis in mouse models, offering potential for novel therapeutic strategies to mitigate pancreatic cancer metastasis.

2018·14citations·D. Gu et al.·Cancers

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Citations

DOI: 10.1016/j.phyplu.2024.100724

Metabolites derived from medicinal plants modulating voltage-gated sodium channel activity: A systematic review

Plant-derived metabolites that modulate voltage-gated sodium channels show significant therapeutic potential for treating neurological disorders with fewer side effects.

2024·0citations·José Luis Estela-Zape et al.·Phytomedicine Plus

Phytomedicine Plus

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Curcumin-loaded emulsome nanoparticles induces apoptosis through p53 signaling pathway in pancreatic cancer cell line PANC-1.

Curcumin-loaded emulsome nanoparticles show potential as an effective and stable therapeutic approach for pancreatic cancer by inducing apoptosis through the p53 signaling pathway.

2024·0citations·Zuleyha Demirci et al.·Toxicology in vitro : an international journal published in association with BIBRA

Toxicology in vitro : an international journal published in association with BIBRA

DOI: 10.3389/fphar.2024.1440979

Alkaloids in Chelidonium majus L: a review of its phytochemistry, pharmacology and toxicology

Chelidonium majus L. contains 94 alkaloids with diverse pharmacological effects, including anti-microbial, anti-inflammatory, anti-viral, and anti-tumor effects, making it a potential medicinal chemistry source.

2024·4citations·Xin-Lan Li et al.·Frontiers in Pharmacology

Frontiers in Pharmacology

DOI: 10.1016/j.chemosphere.2023.140154

U(VI) exposure induces apoptosis and pyroptosis in RAW264.7 cells.

U(VI) exposure induces apoptosis and pyroptosis in RAW264.7 cells, highlighting its immunotoxicity and potential for further research on its toxicity.

2023·6citations·Zhuna Yan et al.·Chemosphere

Chemosphere

DOI: 10.3390/molecules28186588

Insights on Antitumor Activity and Mechanism of Natural Benzophenanthridine Alkaloids

Natural benzophenanthridine alkaloids show inhibitory effects on various cancers and have potential to counteract tumor resistance, with great application potential in the development of antitumor drugs.

2023·7citations·Rui Peng et al.·Molecules

Molecules

DOI: 10.3390/ph16081175

Neuropharmacological Effects of the Dichloromethane Extract from the Stems of Argemone ochroleuca Sweet (Papaveraceae) and Its Active Compound Dihydrosanguinarine

The dichloromethane extract of Argemone ochroleuca stems shows anxiolytic-like, sedative, antidepressant-like, and anticonvulsant effects, with its active compound dihydrosanguinarine showing anxiolytic-like activity.

2023·2citations·Eunice Yáñez-Barrientos et al.·Pharmaceuticals

Pharmaceuticals

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Human CPTP promotes growth and metastasis via sphingolipid metabolite ceramide and PI4KA/AKT signaling in pancreatic cancer cells

CPTP promotes pancreatic cancer cell growth and metastasis through ceramide and PI4KA/AKT signaling, suggesting it as a promising therapeutic target for pancreatic cancer.

2022·8citations·Yanqun Zhang et al.·International Journal of Biological Sciences

International Journal of Biological Sciences

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CDC42 Regulates Cell Proliferation and Apoptosis in Bladder Cancer via the IQGAP3-Mediated Ras/ERK Pathway

CDC42 promotes bladder cancer cell proliferation and suppresses apoptosis by regulating IQGAP3, contributing to the bladder cancer pathogenesis.

2022·10citations·Gang Li et al.·Biochemical Genetics

Biochemical Genetics

Dihydrosanguinarine suppresses pancreatic cancer cells via regulation of mut-p53/WT-p53 and the Ras/Raf/Mek/Erk pathway.

References

Critical role of H2O2 in mediating sanguinarine-induced apoptosis in prostate cancer cells via facilitating ceramide generation, ERK1/2 phosphorylation, and Par-4 cleavage.

Sanguinarine induces apoptosis in prostate cancer cells by promoting ceramide generation, ERK1/2 phosphorylation, and Par-4 cleavage, potentially offering a nontoxic and effective treatment option.

Fluctuations in p53 Signaling Allow Escape from Cell-Cycle Arrest.

Fluctuations in p53 signaling can trigger cells to escape from long-term cell-cycle arrest, resulting in large phenotypic changes.

KRAS targeting antibody synergizes anti-cancer activity of gemcitabine against pancreatic cancer.

RT11-i antibody synergistically increases the antitumor activity of gemcitabine against pancreatic cancer by inhibiting RAS downstream signaling, suggesting potential as a combination treatment option for KRAS mutation pancreatic cancer patients.

Mutant p53 prevents GAPDH nuclear translocation in pancreatic cancer cells favoring glycolysis and 2-deoxyglucose sensitivity.

Mutant p53 in pancreatic cancer cells supports glycolysis and 2-deoxyglucose sensitivity, suggesting a potential personalized therapeutic approach for cancers with mutant TP53 gene.

Simultaneous Inhibition of MEK and Hh Signaling Reduces Pancreatic Cancer Metastasis

Combining hedgehog and MEK signaling inhibitors reduces pancreatic cancer metastasis in mouse models, offering potential for novel therapeutic strategies to mitigate pancreatic cancer metastasis.

Citations

Metabolites derived from medicinal plants modulating voltage-gated sodium channel activity: A systematic review

Plant-derived metabolites that modulate voltage-gated sodium channels show significant therapeutic potential for treating neurological disorders with fewer side effects.

Curcumin-loaded emulsome nanoparticles induces apoptosis through p53 signaling pathway in pancreatic cancer cell line PANC-1.

Curcumin-loaded emulsome nanoparticles show potential as an effective and stable therapeutic approach for pancreatic cancer by inducing apoptosis through the p53 signaling pathway.

Alkaloids in Chelidonium majus L: a review of its phytochemistry, pharmacology and toxicology

Chelidonium majus L. contains 94 alkaloids with diverse pharmacological effects, including anti-microbial, anti-inflammatory, anti-viral, and anti-tumor effects, making it a potential medicinal chemistry source.

U(VI) exposure induces apoptosis and pyroptosis in RAW264.7 cells.

U(VI) exposure induces apoptosis and pyroptosis in RAW264.7 cells, highlighting its immunotoxicity and potential for further research on its toxicity.

Insights on Antitumor Activity and Mechanism of Natural Benzophenanthridine Alkaloids

Natural benzophenanthridine alkaloids show inhibitory effects on various cancers and have potential to counteract tumor resistance, with great application potential in the development of antitumor drugs.

Neuropharmacological Effects of the Dichloromethane Extract from the Stems of Argemone ochroleuca Sweet (Papaveraceae) and Its Active Compound Dihydrosanguinarine

The dichloromethane extract of Argemone ochroleuca stems shows anxiolytic-like, sedative, antidepressant-like, and anticonvulsant effects, with its active compound dihydrosanguinarine showing anxiolytic-like activity.

Human CPTP promotes growth and metastasis via sphingolipid metabolite ceramide and PI4KA/AKT signaling in pancreatic cancer cells

CPTP promotes pancreatic cancer cell growth and metastasis through ceramide and PI4KA/AKT signaling, suggesting it as a promising therapeutic target for pancreatic cancer.

CDC42 Regulates Cell Proliferation and Apoptosis in Bladder Cancer via the IQGAP3-Mediated Ras/ERK Pathway

CDC42 promotes bladder cancer cell proliferation and suppresses apoptosis by regulating IQGAP3, contributing to the bladder cancer pathogenesis.

U(VI) exposure induces apoptosis and pyroptosis in RAW264.7 cells.