Sigurdur Bodvarsson, W. Burlingham, S. Kusaka
Nov 1, 2001
Transplantation of donor–derived malignancies during organ transplantation fortunately is very rare. Discontinuation of immunosuppressive medications under these circumstances has previously resulted in complete tumor rejection. Ectopic adrenocorticotropic hormone (ACTH) production may result in Cushing syndrome and is not an uncommon paraneoplastic feature of small cell carcinoma of the lung. Theoretically, in the organ transplantation setting, the resulting high cortisol levels could suppress a tumor‐rejection immune response. However, to the authors' knowledge, no such a clinical scenario has been described in the literature published to date.