Paper

Drug‐induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine

Published Nov 1, 2006 · C. Valdivia, C T January, B. Gillman

British Journal of Pharmacology

191

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Abstract

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In Vitro Study

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Study Snapshot

Fluoxetine and its metabolite, norfluoxetine, cause drug-induced long QT syndrome by selectively reducing hERG current through direct channel block and indirectly by disrupting channel protein trafficking.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Drug‐induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine

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