Drug effects on salivary glands: dry mouth
Published Jul 1, 2003 · C. S. Cbe
Oral Diseases
181
Citations
2
Influential Citations
Abstract
Objective: To identify drugs associated with the complaint of dry mouth. Materials and Methods: MEDLINE was searched for papers 1980–2002 using keywords, oral, mouth, salivary, drugs, dry mouth and xerostomia, and relevant secondary references were hand-searched. Results: Evidence was forthcoming for a number of xerogenic drugs, especially antimuscarinic agents, some sympathomimetic agents, and agents affecting serotonin and noradrenaline uptake, as well as a miscellany of other drugs such as appetite suppressants, protease inhibitors and cytokines. Conclusion: Dry mouth has a variety of possible causes but drugs – especially those with anticholinergic activity against the M3 muscarinic receptor – are the most common cause of reduced salivation.