Neuroprotective effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline on cultured rat mesencephalic neurons in the presence or absence of various neurotoxins

doi:10.1016/j.brainres.2004.11.019

Paper

DOI: 10.1016/j.brainres.2004.11.019

Neuroprotective effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline on cultured rat mesencephalic neurons in the presence or absence of various neurotoxins

Published Feb 8, 2005 · Y. Kotake, Ryota Taguchi, K. Okuda

Brain Research

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

1MeTIQ shows neuroprotective effects against four dopaminergic neurotoxins in cultured rat mesencephalic neurons, potentially acting as an anti-oxidant.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

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Protective effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline against dopaminergic neurodegeneration in the extrapyramidal structures produced by intracerebral injection of rotenone.

1MeTIQ effectively counteracts the neurotoxic action of rotenone, potentially offering a potential neuroprotective agent.

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MPP+ analogs acting on mitochondria and inducing neuro-degeneration.

Complex I inhibitors, such as MPP(+), can induce neuro-degeneration similar to Parkinson's disease, with potential implications for dietary supplements and herbal teas.

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Neurotoxicity of an endogenous brain amine, 1-benzyl-1,2,3,4-tetrahydroisoquinoline, in organotypic slice co-culture of mesencephalon and striatum

1-benzyl-1,2,3,4-tetrahydroisoquinoline is neurotoxic to tyrosine hydroxylase-positive cells in the ventral mesencephalon, causing cell body shrinkage and slow death of dopaminergic neurons over time.

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Determination method of 1-methyl-1,2,3, 4-tetrahydroisoquinoline, an endogenous parkinsonism-preventing substance, by radioimmunoassay.

This study developed a sensitive and simple radioimmunoassay method for measuring endogenous 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), which may help evaluate Parkinson's disease progression or prognosis.

2002·7citations·K. Okuda et al.·Life sciences

Life sciences

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Stereoselective effect of (R)- and (S)-1-methyl-1,2,3,4-tetrahydroisoquinolines on a mouse model of Parkinson’s disease

(R)-1-MeTIQ, not (S)-1-MeTIQ, plays a crucial role in protection against Parkinson's disease-like symptoms in mice, suggesting enantiomeric biochemical events may play a role in Parkinson's disease pathogenesis.

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Brain Research Bulletin

Citations

DOI: 10.1016/j.tchem.2024.100087

-Proline catalyzed synthesis of biologically promising heterocycles under sustainable conditions

L-proline catalyzed organic reactions enable the sustainable synthesis of biologically promising heterocycles under environmentally benign conditions, offering valuable tools for bio-active compound manufacturing.

2024·1citation·Rajiv Karmakar et al.·Tetrahedron Chem

Tetrahedron Chem

DOI: 10.1016/j.heliyon.2024.e30788

A comprehensive review on the progress and challenges of tetrahydroisoquinoline derivatives as a promising therapeutic agent to treat Alzheimer's disease

THIQ derivatives show promising potential as therapeutic agents for Alzheimer's disease due to their neuroprotective, anti-inflammatory, and antioxidative properties.

2024·2citations·Danesh Thangeswaran et al.·Heliyon

Heliyon

DOI: 10.1021/acschemneuro.2c00516

Quantitative Determination of Endogenous Tetrahydroisoquinolines, Potential Parkinson's Disease Biomarkers, in Mammals.

Endogenous tetrahydroisoquinoline metabolites show promise as potential Parkinson's disease biomarkers, but require sensitive and specific analytical techniques for accurate detection in various mammalian fluids and tissues.

2022·3citations·E. Hényková et al.·ACS chemical neuroscience

ACS chemical neuroscience

DOI: 10.1016/J.PHAREP.2019.06.016

1-Methyl-1,2,3,4-tetrahydroisoquinoline — The toxicological research on an exo/endogenous amine with antidepressant-like activity — In vivo, in vitro and in silico studies

1MeTIQ shows potential as an effective and safe antidepressant substance with neuroprotective, antioxidant, and antidepressant-like effects in the CNS.

2019·3citations·E. Możdżeń et al.·Pharmacological Reports

Pharmacological Reports

DOI: 10.1021/acs.orglett.7b01274

Identification of an Imine Reductase for Asymmetric Reduction of Bulky Dihydroisoquinolines.

The new imine reductase from Stackebrandtia nassauensis (SnIR) demonstrates 25- to 1400-fold greater catalytic efficiency for 1-methyl-3,4-dihydroisoquinoline (1-Me DHIQ) and can efficiently convert

2017·40citations·Hao Li et al.·Organic letters

Organic letters