In vivo studies were done on mongrel dogs to determine the effect of angiotensin II on renal electrolyte excretion. Angiotensin II was infused directly into the left renal artery at a rate of 1 ng/kg/min. Angiotensin produced consistent reductions in the excretion of Na+, K+, and Cl- in the left kidney. These reductions could not be attributed to decreases in GFR or RPF. Electrolyte excretion by the right kidney was constant. These data are consistent with the hypothesis that angiotensin II may function as an intrarenal, antinatriuretic hormone.

Angiotensin II may function as an intrarenal, antinatriuretic hormone, reducing Na+, K+, and Cl- excretion in the left kidney without affecting GFR or RPF.

The effect of angiotensin II on electrolyte excretion by the renal tubules.

Key Takeaway: Angiotensin II may function as an intrarenal, antinatriuretic hormone, reducing Na+, K+, and Cl- excretion in the left kidney without affecting GFR or RPF.