The inhibitory effect of bis[2-[(E)-2-octenoylamino]ethyl] disulfide on the cyclooxygenase pathway.

doi:10.1248/CPB.37.778

Paper

The inhibitory effect of bis[2-[(E)-2-octenoylamino]ethyl] disulfide on the cyclooxygenase pathway.

Published Mar 25, 1989 · T. Mimura, H. Nakajima, K. Tsujikawa

Chemical & pharmaceutical bulletin

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Abstract

Bis[2-[(E)-2-octenoylamino]ethyl] disulfide (compd. I-3) inhibited collagen- and arachidonic acid-induced rat platelet aggregation, although not adenosine 5'-diphosphate (ADP)-induced rat platelet aggregation. Based on these results, we then investigated the inhibitory effect of compd. I-3 on thromboxane B2 formation from arachidonic acid in rat platelets, and prostaglandin I2 formation in rat aortae. Compound I-3 inhibited both thromboxane B2 and prostaglandin I2 formation, suggesting that it has an inhibitory effect on cyclooxygenase. The inhibitory effect of compd. I-3 was confirmed in experiments using a crude preparation of sheep seminal vesicle microsomal prostaglandin synthetase. These findings suggested that compd. I-3 has an inhibitory effect on cyclooxygenase activity, like nonsteroidal anti-inflammatory drugs.

In Vitro Study

Study Snapshot

Bis[2-[(E)-2-octenoylamino]ethyl] disulfide (compd. I-3) inhibits cyclooxygenase activity, potentially acting as a nonsteroidal anti-inflammatory drug.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

The inhibitory effect of bis[2-[(E)-2-octenoylamino]ethyl] disulfide on the cyclooxygenase pathway.

References

Prostaglandin Synthetase Inhibitors I

Prostaglandin synthetase inhibitors, such as sulindac and diflunisal, show promise as potential antiarthritic drugs due to their safety and selectivity in inhibiting prostaglandin synthesis.

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