Anti-Proliferative Effect of Camellianin A in Adinandra nitida Leaves and Its Apoptotic Induction in Human Hep G2 and MCF-7 Cells

doi:10.3390/molecules15063878

Paper

Anti-Proliferative Effect of Camellianin A in Adinandra nitida Leaves and Its Apoptotic Induction in Human Hep G2 and MCF-7 Cells

Published May 28, 2010 · Han Gao, Benguo Liu, Feng Liu

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Abstract

Leaves of Adinandra nitida constitute a kind of flavonoid-rich plant food. In this study, camellianin A, the main flavonoid in the leaves of Adinandra nitida, was prepared and identified by high performance liquid chromatography-photodiode array detector-electrospray ionization mass spectrometry (HPLC-PDA-ESI/MS). In the anticancer assay, it was found camellianin A could inhibit the proliferation of the human hepatocellular liver carcinoma Hep G2 and human breast adenocarcinoma MCF-7 cell lines in a dose-dependent manner and induce the significant increase of the G0/G1 cell population. After treated by camellianin A, phosphatidylserine of Hep G2 and MCF-7 cells could translocate significantly to the surface of the membrane. The increase of an early apoptotic population of Hep G2 and MCF-7 cells was observed. It was concluded that camellianin A not only affected the progress of the cell cycle, but also induced cells to enter into apoptosis.

In Vitro Study

Study Snapshot

Camellianin A in Adinandra nitida leaves inhibits cell proliferation and induces apoptosis in human cancer cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Anti-Proliferative Effect of Camellianin A in Adinandra nitida Leaves and Its Apoptotic Induction in Human Hep G2 and MCF-7 Cells

References

Preparative separation of flavonoids in Adinandra nitida leaves by high-speed counter-current chromatography and their effects on human epidermal carcinoma cancer cells

Adinandra nitida leaves contain flavonoids that significantly inhibit human epidermal carcinoma cancer cell growth, with concentration-dependent effects.

PREPARATION AND ANTIOXIDANT ACTIVITY OF CAMELLIANIN A FROM ADINANDRA NITIDA LEAVES

Camellianin A, a natural antioxidant found in Adinandra nitida leaves, can be easily prepared and widely used in the food and pharmaceutical industries as a functional ingredient.

CHRACTERIZATION AND 1,1‐DIPHENYL‐2‐PICRYLHYDRAZYL RADICAL SCAVENGING ACTIVITY OF METHANOL AND SUPERCRITICAL CARBON DIOXIDE EXTRACTS FROM LEAVES OF ADINANDRA NITIDA

Leaves of Adinandra nitida show high antioxidant and flavonoid activity, making them a potential new source for food and phytopharmaceutical products.

Quantitative and qualitative analysis of flavonoids in leaves of Adinandra nitida by high performance liquid chromatography with UV and electrospray ionization tandem mass spectrometry detection

HPLC-UV-ESI tandem mass spectrometry identified six flavonoids in Adinandra nitida leaves, including rhoifolin, and established a quality control method for Shiyacha.

Antioxidant activity of a flavonoid-rich extract of Hypericum perforatum L. in vitro.

The flavonoid-rich extract of Hypericum perforatum L. exhibits antioxidant activity due to its free radical scavenging, metal-chelation, and reactive oxygen quenching properties.

Citations

Inhibitory Mechanism of Camellianin A against α-Glucosidase: In Vitro and Molecular Simulation Studies

Camellianin A, found in Adinandra nitida leaves, exhibits excellent -glucosidase inhibitory activity, providing a potential reference for developing natural -glucosidase inhibitors.

Disruption of NADPH Homeostasis by Total Flavonoids from Adinandra nitida Merr. ex Li Leaves Triggers ROS-Dependent p53 Activation Leading to Apoptosis in Non-Small Cell Lung Cancer Cells.

Total flavonoids from Adinandra nitida Merr. ex Li leaves can inhibit non-small cell lung cancer growth by disrupting NADPH homeostasis and triggering apoptosis in cancer cells.

Chemical constituents of Adinandra glischroloma Hand.–Mazz. and their chemotaxonomic significance

Adinandra glischroloma leaves contain fourteen known compounds, which can be used as chemotaxonomic markers to differentiate it from other Adinandra species in Vietnam.

Chemical constituents and biological activities of the leaves of Adinandra megaphylla

Leaves of Adinandra megaphylla contain new compounds and flavonoid glycosides, which inhibit -glucosidase activity.

Shibi Tea (Adinandra nitida) and Camellianin A Alleviate CCl4-Induced Liver Injury in C57BL-6J Mice by Attenuation of Oxidative Stress, Inflammation, and Apoptosis

Shibi tea and Camellianin A can protect against carbon tetrachloride-induced liver injury by reducing oxidative stress, inflammation, and apoptosis in mice.

New triterpene and nor-diterpene derivatives from the leaves of Adinandra poilanei

New compounds from Adinandra poilanei leaves show strong inhibition of α-glucosidase activity and pomolic acid exhibits strong cytotoxicity against cancer cell lines.

Complete chloroplast genome of novel Adinandra megaphylla Hu species: molecular structure, comparative and phylogenetic analysis

The chloroplast genome of Adinandra megaphylla Hu shows highly conserved gene content and structure, with potential for phylogenetic reconstruction using matK sequences from Pentaphylacaceae species.