Paper
Preventive Effect of Cozaar on the Long-Term Intensive Exercise Induced Heart Fibrosis in rats
Published 2014 · Zheng Hai-yin
Progress in Modern Biomedicine
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Abstract
Objective: This study examined the antifibrotic effect of Cozaar, an angiotensin II type 1 receptor antagonist, in an animal model of heart fibrosis induced by long-term intense exercise. Methods: Male Wistar rats were randomly distributed into 4 experimental groups: Exercise, Exercise plus losartan, Sedentary and Sedentary plus Cozaar. Exercise groups were conditioned to run vigorously for 16 weeks. Cozaar was orally administered daily before each training session(50 mg/kg/day). After euthanasia, heart hypertrophy was evaluated by histological studies; ventricular collagen deposition was quantified by histological and biochemical studies; and protein expression of transforming growth factor-b1, fibronectin-1, matrix metalloproteinase-2, tissue inhibitor of metalloproteinase-1, procollagen-I and procollagen-III was evaluated in all 4 cardiac chambers. Results: Daily intensive exercise caused hypertrophy in the left ventricular heart wall and originated collagen deposition in the right ventricle. Additionally long-term intensive exercise induced a significant increase in protein synthesis of the major fibrotic markers in both atria and in the right ventricle. Cozaar treatment was able to reduce all increases of protein synthesis of the major fibrotic markers, although it could not completely ameliorate the the ratio between body and heart weight caused by intensive exercise. Conclusion: Cozaar treatment prevents the heart fibrosis induced by endurance exercise in training animals, however, it could not completely reverse the heart hypertrophy.
RCT
Animal StudyCozaar treatment prevents heart fibrosis induced by intense exercise in rats, but cannot completely reverse heart hypertrophy.
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