Effect of cycloheximide on unidirectional sodium fluxes in the jejunum after cholera exotoxin exposure.

doi:10.1016/S0016-5085(70)80154-8

Paper

Effect of cycloheximide on unidirectional sodium fluxes in the jejunum after cholera exotoxin exposure.

Published Jun 1, 1970 · D. Grayer, H. Serebro, F. Iber

Gastroenterology

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27

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

Cycloheximide prevents fluid production in intestinal loops exposed to cholera exotoxin by blocking the increased flux of sodium and water into the loop.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Effect of cycloheximide on unidirectional sodium fluxes in the jejunum after cholera exotoxin exposure.

References

PATHOGENESIS OF EXPERIMENTAL CHOLERA

Choleragen, a diarrheagenic protein from Vibrio cholerae, is highly active in inducing experimental cholera in rabbit models and increasing vascular permeability in skin, suggesting choleragenicity and increased vascular permeability are linked.

Inhibition of cholera toxin action in the rabbit by cycloheximide.

Cycloheximide prevents cholera toxin-induced fluid production in rabbits, suggesting that fluid secretion originates in the crypts of Lieberkühn.

Absorption of d-Glucose by the Rabbit Jejunum during Cholera Toxin-induced Diarrhoea

Cholera toxin-induced diarrhea in rabbits is primarily due to decreased intestinal absorption, rather than increased intestinal secretion or both factors.

Inhibition of protein synthesis in vitro by cycloheximide and related glutarimide antibiotics.

Cycloheximide and related glutarimide antibiotics effectively inhibit protein synthesis in vitro, with E-73 being slightly more effective than the other glutarimides.

Cycloheximide: Aspects of Inhibition of Protein Synthesis in Mammalian Cells

Cycloheximide and acetoxy-cycloheximide specifically inhibit protein synthesis in L-cells and rat liver, but have no effect on protein synthesis in Escherichia coli.

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