Paper
The effect of gabapentin on the expression of FGF-2 and FGFR1 in dorsal root ganglion neurons of arthritis rats
Published Jan 1, 2015 · Sun Dex
Immunological Journal
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Abstract
This study designed to explore the effect of gabapentin on the expression of FGF-2 and FGFR1 in dorsal root ganglion neurons of arthritis rats. Adult healthy male SD rats were randomly divided into 3 groups(n=30): control group, model group and gabapentin group. The model and gabapentin group rats were injected with complete Freud adjuvant to induce arthritis. The gabapentin group rats were injected with gabapentin once a day from the 7thday to 14 thday after adjuvant injection. The plantar thickness and paw withdrawal mechanical threshold(PWMT) of rats were record at the 1st, 4th, 7th, 10 th, 14thday; the expressions of FGF-2 and FGFR1 were observed at the 7thand 14 thday. Compared with control group rats, the model and gabapentin group rats showed the symptoms of arthritis, decreased PWMT(P 0.05), and increased expression of FGF-2 and FGFR1 in the dorsal root ganglion. After gabapentin injection, the PWMT was increased, FGF-2 and FGFR1 expressions were decreased. This study suggests that gabapentin can relieve the suffering of arthritis and decrease the expression of FGF-2 and FGFR1 in dorsal root ganglia.
RCT
Animal StudyGabapentin can relieve arthritis symptoms and decrease the expression of FGF-2 and FGFR1 in dorsal root ganglia in arthritis rats.
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