Effect of low-dose aprotinin on homeostasis of patient during cardiopulmonary bypass
C. Lan
2000
Citations
0
Citations
Quality indicators
Journal
Journal of Bengbu Medicinae College
Semantic Scholar
Key Takeaway Key Takeaway: Low dose aprotinin can reduce postoperative bleeding in cardiopulmonary bypass patients similarly to high dose aprotinin, economizing medicine.
Abstract
Objective:To observe the haemostatic effect of low dose aprotinin during cardiopulmonary bypass(CPB). Methods:Thirty patients scheduled for elective valve surgery were randomly divided into two groups:High dose aprotinin group(control group,CG) and low dose aprotinin group(research group,RG). Following hemodilution,in RG,a bolus of 1.0×10 4 kIU aprotinin was administered intravenously after anesthesia induction,the same dose of aprotinin was added to the priming liquid of oxygentor and 0.5×10 4 kIU aprotinin was transfused after CPB. In CG,the double dose of aprotinin was given at the same time point as in RG. Results:Administration of low dose aprotinin reduced postoperative blood loss. During first 24 h after the operation,the chest drainage of RG(345.9±162.3 ml) was less than that of CG by 35%(529.0±131.9 ml). Active coagulant time of blood was prolonged obviously at post heparinize and after anti heparin,there was no other obvious change. Conclusions:Compared with high dose aprotinin,low dose aprotinin can reduce the postoperative bleeding in patients of CPB similarly. There is advantage of economizing medicine. [