Effect of local anesthetic ropivacaine on isolated rat liver mitochondria.

doi:10.1016/S0006-2952(99)00172-0

Paper

Effect of local anesthetic ropivacaine on isolated rat liver mitochondria.

Published Sep 15, 1999 · Aristide Floridi, M. D. Padova, Rosaria Barbieri

Biochemical pharmacology

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15

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1

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

Ropivacaine has minimal effect on rat liver mitochondrial metabolism, contributing to its reduced toxicity due to low liposolubility and minimal perturbation of mitochondrial metabolism.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Effect of local anesthetic ropivacaine on isolated rat liver mitochondria.

References

Citations

Ropivacaine- and bupivacaine-induced death of rabbit annulus fibrosus cells in vitro: involvement of the mitochondrial apoptotic pathway.

Local anesthetics, such as ropivacaine and bupivacaine, can induce apoptosis of rabbit annulus fibrosus cells in vitro, with the mitochondrial pathway playing a partial role in this process.

Toxicity of nano zinc oxide to mitochondria

Nano zinc oxide can impair the respiratory chain and lead to energy dissipation, oxidative stress, and even apoptosis in isolated rat liver mitochondria.

Effects of anesthetics on mitochondrial signaling and function.

Anesthetics during anesthesia can impair mitochondrial structure and function, potentially leading to cell damage and decreased ATP production.

Intraneural Injection and Peripheral Nerve Injury

Intraneural injections to 0.03% for peripheral nerve blockade in the thigh, with a higher incidence in the calf and thigh.

Cytotoxicity of Local Anesthetics in Human Neuronal Cells

Local anesthetics can cause cell death in human neuronal cells, with bupivacaine and lidocaine being the most toxic, and their cytotoxicity may be mediated by various pathways.

Pathophysiology of Peripheral Nerve Injury During Regional Anesthesia

Local anesthetics can cause peripheral nerve damage, with elevated intracellular calcium levels playing a central role, and tourniquets and ischemia contributing to neuronal injury.

The Effects of Local Anesthetics on Bile Flow, Potassium Equilibrium and Oxygen Consumption in the Perfused Rat Liver

Local anesthetics, lidocaine, bupivacaine, and ropivacaine, cause immediate changes in liver function, but these effects do not cause lasting postoperative disturbances like cholestasis or jaundice.

Drug-induced mitochondrial toxicity

Drugs that disrupt mitochondrial function can cause cell death and may increase the progression of existing mitochondrial diseases.