J. W. Carpender, R. R. Lanier
Dec 1, 1950
The success of irradiation in cancer therapy is dependent in most instances on the differential sensitivity of cancer cells as compared to the cells of normal surrounding tissue. Too often this differential is so small that adequate irradiation is impossible. The exact mode of action of ionizing radiation, when successful, and the time of such action with respect to the phases of cell division are not definitely known, although these problems have been the subject of extensive investigations. The recent work of Kidder and associates (1), showing that guanazolo (5-amino 7-hydroxy-1 H-V-triazolo (d) pyrimidine) inhibits guanine metabolism in certain lower organisms and in tumors where guanine is an essential metabolite for growth, suggested to us that a study of the effect of ionizing radiation in tumors so inhibited might yield some worth-while information. At the outset, it was realized that there were three possible results to be expected: (1)There would be no change in the effectiveness of radiation. (2...