Paper

Rate-dependent effects of sematilide on action potential duration in isolated guinea pig ventricular myocytes.

Published Oct 1, 1994 · DOI · T. Sawanobori, H. Adaniya, T. Namiki

The Journal of pharmacology and experimental therapeutics

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Abstract

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In Vitro Study

Study Snapshot

Sematilide prolongs action potential duration in guinea pig ventricular myocytes by blocking the rapidly activating component of the delayed outward K+ current, with a reverse use-dependent effect at 2.5 Hz.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Rate-dependent effects of sematilide on action potential duration in isolated guinea pig ventricular myocytes.

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