Effects of perinatal combined exposure to 1,4-dichlorobenzene and 1,1-dichloro-2, 2-bis (p-chlorophenyl) ethylene on rat male offspring.

doi:10.1111/J.1742-7843.2004.950306.X

Paper

Effects of perinatal combined exposure to 1,4-dichlorobenzene and 1,1-dichloro-2, 2-bis (p-chlorophenyl) ethylene on rat male offspring.

Published Sep 1, 2004 · Y. Makita

Basic & clinical pharmacology & toxicology

Q2 SJR score

9

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0

Influential Citations

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Abstract

1,4-Dichlorobenzene (DCB) is used as an air deodorant or a moth repellent and 1, 1-dichloro-2, 2-bis (p-chlorophenyl) ethylene (p,p'-DDE) is a persistent metabolite of 1, 1, 1-trichloro-2, 2-bis (p-chlorophenyl) ethane (DDT) which was used as a pesticide before. DCB concentrations of residential air and oral p,p'-DDE intake through marine products are demonstrated to be very high in Japan and consequently, foetuses and neonates may be exposed much more to DCB and/or p,p'-DDE via the maternal body. It has recently been reported that DCB is oestrogenic and that p,p'-DDE is antiandrogenic. Therefore, the combined effects of perinatal exposure to DCB and p,p'-DDE have been investigated in rat male offspring of dams ingesting these contaminants during the perinatal period from gestational day 1 to postpartum day 21 for 42 days. In this study, no obvious developmental effects on male offspring have been recognized until 6 weeks of age, following oral administration of 25 ppm DCB (approximately 2 mg/kg) and/or 125 ppm p,p'-DDE (approximately 10 mg/kg) to dams. In contrast to female offspring, the thymus weight in male offspring was not affected by DCB at 6 weeks of age, but there might be sexual differences concerning the effects of DCB on the thymus.

Non-RCT

Animal Study

Study Snapshot

Perinatal exposure to 1,4-dichlorobenzene and 1,1-dichloro-2,2-bis (p-chlorophenyl) ethylene has no obvious developmental effects on rat male offspring until 6 weeks of age, with potential sexual differences in thymus effects.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Effects of perinatal combined exposure to 1,4-dichlorobenzene and 1,1-dichloro-2, 2-bis (p-chlorophenyl) ethylene on rat male offspring.

References

Systemic Effects of Orally Administered p, p′‐DDE on Immature Male Wistar Rats during Pubertal Period

Orally administered p, p′-DDE during the pubertal period does not cause overt signs of toxicity in immature male rats, with no effect on physical development, sexual maturation, or serum biochemistry.

In vitro and in vivo estrogenicity and toxicity of o‐, m‐, and p‐dichlorobenzene

O, m, and p-dichlorobenzene are estrogenic compounds with potential toxicity to gonads, but their estrogenic activity may be influenced by other factors.

Urinary 2,5-Dichlorophenol as Biological Index for p-Dichlorobenzene Exposure in the General Population

Urinary 2,5-dichlorophenol is a suitable biological index for monitoring low-level p-dichlorobenzene exposure in the general population due to its strong association with exposure concentrations.

Effects of subchronic exposure to a complex mixture of persistent contaminants in male rats: systemic, immune, and reproductive effects.

Subchronic oral exposure to a complex mixture of persistent environmental contaminants can cause hepatotoxicity, decreased immune function, and potentially affect reproductive function in male rats.

Inhalation toxicokinetics of p-dichlorobenzene and daily absorption and internal accumulation in chronic low-level exposure to humans

Chronic low-level exposure to p-dichlorobenzene in humans leads to high absorption rates and requires long time for complete elimination, with urinary excretion being the major route for elimination.

Citations

Preconception and/or preimplantation exposure to a mixture of environmental contaminants altered fetoplacental development and placental function in a rabbit model.

Maternal exposure to environmental contaminants during crucial developmental windows mildly impaired fetoplacental development but disturbed fetal blood biochemistry and placental gene expression, potentially impacting offspring phenotype.

1,4‐Dichlorobenzene [MAK Value Documentation, 2018]

1,4-dichlorobenzene is a carcinogenic substance with a non-genotoxic mechanism, and its exposure is unlikely to cause damage to embryos or foetuses when the MAK value is observed.

Effects of perinatal, combined exposure to 1,4-dichlorobenzene and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene on rat female reproductive system.

Perinatal exposure to 1,4-dichlorobenzene and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene can cause a decrease in ovarian weight in matured female rats, potentially leading to reproductive dysfunction.

Normal Development of Reproductive System in Rat Male Offspring Following Perinatal Combined Exposure to p,p′-DDE and 1,4-Dichlorobenzene

Perinatal combined exposure to p,p′-DDE and 1,4-dichlorobenzene does not cause developmental problems in rat male offspring until maturation.

Effects of concurrent exposure to tributyltin and 1,1-dichloro-2,2 bis (p-chlorophenyl) ethylene (p,p'-DDE) on immature male Wistar rats.

Concurrent exposure to tributyltin and 1,1-dichloro-2,2 bis (p-chlorophenyl) ethylene (p,p'-DDE) in immature male Wistar rats does not significantly affect sexual maturation, male reproductive organ development, or sperm production

Parenteral paradichlorobenzene exposure reduces sperm production, alters sperm morphology and exhibits an androgenic effect in rats and mice.

PDCB reduces sperm production and alters sperm morphology in rats and mice, but exhibits an androgenic effect independent of androgen receptor binding.