Ocular effects of oral contraceptives. II. Studies in the rhesus monkey.

doi:10.1016/S0015-0282(16)41358-0

beta

Ocular effects of oral contraceptives. II. Studies in the rhesus monkey.

V. Drill, D. P. Martin, P. Golway

Sep 1, 1975

Citations

Journal

Fertility and sterility

Full text

Semantic Scholar

Key Takeaway

Key Takeaway: Oral contraceptives do not cause ocular lesions or significant fundic lesions in female rhesus monkeys at doses up to 50 times the human dose.

Abstract

Oral contraceptives were administered cyclically to 96 female rhesus monkeys for 5 years. Forty-eight animals received Enovid-E and 48 were treated with Ovulen at doses 1, 10, and 50 times the human dose. Ophthalmic lesions did not occur at any of the dose levels employed. Significant fundic lesions, including papilledema, venous dilatation, venous retinal thrombosis, or arterial retinal thrombosis, did not develop in any of the treated animals.

Text copied to clipboard

copied to clipboard