Paper
EFFECTS OF IRON DEFICIENCY EXCLUSIVE OF ANAEMIA
Published Oct 1, 1978 · P. Dallman, E. Beutler, C. Finch
British Journal of Haematology
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Abstract
EFFECTS O F IRON DEFICIENCY EXCLUSIVE OF ANAEMIA The symptoms of iron deficiency are partly due to the compromised delivery of oxygen to the tissues that results from a decrease in the concentration of hacmoglobin (Anderson & Barkve, 1970; Viteri & Torun, 1974; Gardner et a l , 1975). However, iron deficiency also results in depletion of iron-containing compounds in solid tissues (Beutlcr, I 964; Jacobs, I 969; Fairbanks et al, 1971; Dallman, I974), and it is reasonable to expect this to contribute to the clinical manifestations. While it is difficult to separate the physiological consequences of deficiencies in tissue iron compounds from those of anaemia, there has recently been some success in making this distinction by the demonstration of impaired exercise tolerance in the rat and of defects in the immune response in man, both of which occur indepcndcntly of anaemia. Such findings have stimulated renewed interest in delineating the links between disordered function and biochemical abnormalities in iron deficiency.
Highly CitedIron deficiency can cause impaired exercise tolerance and immune response, independent of anaemia, highlighting the need to link disordered function and biochemical abnormalities in iron deficiency.
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