Paper
Effects of ochratoxin A metabolites on yeast phenylalanyl-tRNA synthetase and on the growth and in vivo protein synthesis of hepatoma cells.
Published Nov 1, 1983 · Edmond E. Creppy, F. C. Størmer, Daniel Kern
Chemico-biological interactions
Q1 SJR score
62
Citations
1
Influential Citations
Abstract
Abstract removed due to Elsevier request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Study Snapshot
Key takeawayOchratoxin A metabolite (4R)-4-hydroxyochratoxin A inhibits yeast phenylalanyl-tRNA synthetase and hepatoma cell growth, while ochratoxin alpha does not affect these processes.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Balkan (endemic) nephropathy and foodborn ochratoxin A: preliminary results of a survey of foodstuffs.
Ochratoxin A contamination in foodstuffs is more frequent in areas with Balkan endemic nephropathy, suggesting higher exposure to foodborne ochratoxin A in these areas.
2009·177citations·P. Krogh et al.·Acta pathologica et microbiologica Scandinavica. Section B, Microbiology
Acta pathologica et microbiologica Scandinavica. Section B, Microbiology
Oxidation of Two Hydroxylated Ochratoxin A Metabolites by Alcohol Dehydrogenase
Alcohol dehydrogenase can oxidize only (4R)-4-hydroxyochratoxin A and 10-hydroxyochratoxin A, with a Km and turnover number of 110 M and 0.1 s1.
1983·7citations·C. Syvertsen et al.·Applied and Environmental Microbiology
Applied and Environmental Microbiology
Formation of (4R)- and (4S)-4-hydroxyochratoxin A and 10-hydroxyochratoxin A from Ochratoxin A by rabbit liver microsomes
Rabbit liver microsomes form four metabolites from ochratoxin A, with cytochrome P-450 catalyzing their formation.
1983·72citations·F. C. Størmer et al.·Applied and Environmental Microbiology
Applied and Environmental Microbiology
Effects of two metabolites of ochratoxin A, (4R)-4-hydroxyochratoxin A and ochratoxin alpha, on immune response in mice
(4R)-4-hydroxyochratoxin A is an effective immunosuppressor in mice, while ochratoxin alpha is ineffective, suggesting a possible mode of action.
1983·116citations·E. Creppy et al.·Infection and Immunity
Infection and Immunity
Metabolism of ochratoxin A by primary cultures of rat hepatocytes
Ochratoxin A is metabolized by rat hepatocytes at 37 degrees, with maximum accumulation of (4R)-4-hydroxyochratoxin A after 48 hours of incubation.
1982·34citations·C. Hansen et al.·Applied and Environmental Microbiology
Applied and Environmental Microbiology
Formation of (4R)- and (4S)-4-hydroxyochratoxin A from ochratoxin A by liver microsomes from various species
Different species of liver microsomes form (4R)- and (4S)-4-hydroxyochratoxin A from ochratoxin A, with the microsomal hydroxylation system being a cytochrome P-450.
1981·69citations·F. C. Størmer et al.·Applied and Environmental Microbiology
Applied and Environmental Microbiology
Action of Ochratoxin a on cultured hepatoma cells—reversion of inhibition by phenylalanine
Ochratoxin A effectively inhibits protein synthesis in hepatoma tissue culture cells, and phenylalanine can reverse this inhibition, potentially causing liver and kidney damage in higher animals.
1979·63citations·E. Creppy et al.·FEBS Letters
FEBS Letters
Porcine Nephropathy Induced by Long-Term Ingestion of Ochratoxin A
Long-term ingestion of ochratoxin A in pig feed can cause progressive kidney damage, but terminal renal failure was not reached in this study.
1979·59citations·P. Krogh et al.·Veterinary Pathology
Veterinary Pathology
Citations
Practical Strategies to Reduce Ochratoxin A in Foods
Food processing methods and additives like baking soda and sugars can help reduce ochratoxin A in foods, ensuring food safety for human consumption.
2024·5citations·Hyun Jung Lee et al.·Toxins
Toxins
Detection, Contamination, Toxicity, and Prevention Methods of Ochratoxins: An Update Review.
Ochratoxin A (OTA) contamination in crops and cereals can be reduced through various methods, including inhibition of adulteration and decontamination or detoxification of food.
2021·28citations·M. Samuel et al.·Journal of agricultural and food chemistry
Journal of agricultural and food chemistry
Human Proximal Tubule Epithelial Cells (HK-2) as a Sensitive In Vitro System for Ochratoxin A Induced Oxidative Stress
HK-2 cells are more sensitive to ochratoxin A-induced toxicity than LLC-PK1 cells, and OTA can cause significant oxidative stress in HK-2 cells.
2021·12citations·E. García-Pérez et al.·Toxins
Toxins
Ochratoxin A Induces Oxidative Stress in HepG2 Cells by Impairing the Gene Expression of Antioxidant Enzymes
Ochratoxin A induces oxidative stress in HepG2 cells by impairing the gene expression of antioxidant enzymes, suggesting oxidative stress as a contributing factor in its toxicity.
2021·22citations·E. García-Pérez et al.·Toxins
Toxins
Effects of combined treatment with ochratoxin A and citrinin on oxidative damage in kidneys and liver of rats
Resveratrol effectively restores glutathione levels in all tissues but does not affect MDA concentration or DNA damage caused by combined ochratoxin A and citrinin treatment in rats.
2018·26citations·D. Rašić et al.·Toxicon
Toxicon
Tissue distribution of ochratoxin A in pigs after administration of two-levels contaminated diets
Ochratoxin A levels in pigs exposed to two-level contaminated diets show a linear dose-response relationship, with bile being a potential tool for assessing exposure.
2017·21citations·A. Altafini et al.·World Mycotoxin Journal
World Mycotoxin Journal
Structure–activity relationship of ochratoxin A and synthesized derivatives: importance of amino acid and halogen moiety for cytotoxicity
Substituting the amino acid moiety of ochratoxin A with tyrosine or alanine almost completely prevents its adverse effects on human renal cells, while halogen moiety changes have minor effects.
2017·15citations·U. Rottkord et al.·Archives of Toxicology
Archives of Toxicology