Effects of ochratoxin A metabolites on yeast phenylalanyl-tRNA synthetase and on the growth and in vivo protein synthesis of hepatoma cells.

doi:10.1016/0009-2797(83)90160-6

Paper

DOI: 10.1016/0009-2797(83)90160-6

Effects of ochratoxin A metabolites on yeast phenylalanyl-tRNA synthetase and on the growth and in vivo protein synthesis of hepatoma cells.

Published Nov 1, 1983 · Edmond E. Creppy, F. C. Størmer, Daniel Kern

Chemico-biological interactions

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Abstract

Abstract removed due to Elsevier request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Study Snapshot

Key takeawayOchratoxin A metabolite (4R)-4-hydroxyochratoxin A inhibits yeast phenylalanyl-tRNA synthetase and hepatoma cell growth, while ochratoxin alpha does not affect these processes.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Practical Strategies to Reduce Ochratoxin A in Foods

Food processing methods and additives like baking soda and sugars can help reduce ochratoxin A in foods, ensuring food safety for human consumption.

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Effects of combined treatment with ochratoxin A and citrinin on oxidative damage in kidneys and liver of rats

Resveratrol effectively restores glutathione levels in all tissues but does not affect MDA concentration or DNA damage caused by combined ochratoxin A and citrinin treatment in rats.

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Tissue distribution of ochratoxin A in pigs after administration of two-levels contaminated diets

Ochratoxin A levels in pigs exposed to two-level contaminated diets show a linear dose-response relationship, with bile being a potential tool for assessing exposure.

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Advanced technologies and exploring competing endogenous RNAs (ceRNA) are recommended for studying epigenetic mechanisms of ochratoxin A toxicity.

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