Paper
Effects of exercise and airway clearance (positive expiratory pressure) on mucus clearance in cystic fibrosis: a randomised crossover trial
Published Mar 7, 2019 · T. Dwyer, E. Daviskas, R. Zainuldin
European Respiratory Journal
37
Citations
1
Influential Citations
Abstract
Exercise improves mucus clearance in people without lung disease and those with chronic bronchitis. No study has investigated exercise alone for mucus clearance in cystic fibrosis (CF). The aim of this study was to compare the effects of treadmill exercise to resting breathing and airway clearance with positive expiratory pressure (PEP) therapy on mucus clearance in adults with CF. This 3-day randomised, controlled, crossover trial included 14 adults with mild to severe CF lung disease (forced expiratory volume in 1 s % predicted 31–113%). Interventions were 20 min of resting breathing (control), treadmill exercise at 60% of the participant's peak oxygen consumption or PEP therapy (including huffing and coughing). Mucus clearance was measured using the radioaerosol technique and gamma camera imaging. Treadmill exercise improved whole lung mucus clearance compared to resting breathing (mean difference 3%, 95% CI 2–4); however, exercise alone was less effective than PEP therapy (mean difference −7%, 95% CI −6– −8). When comparing treadmill exercise to PEP therapy, there were no significant differences in mucus clearance from the intermediate and peripheral lung regions, but significantly less clearance from the central lung region (likely reflecting the huffing and coughing that was only in PEP therapy). It is recommended that huffing and coughing are included to maximise mucus clearance with exercise. Exercise and PEP therapy significantly improve mucus clearance in CF, but PEP therapy clears more mucus than exercise alone http://ow.ly/d7j530nvUOM
RCT
Rigorous JournalTreadmill exercise improves mucus clearance in cystic fibrosis patients, but PEP therapy clears more mucus than exercise alone.
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