Efficacy of Porcine Secretin in Children with Autism and Pervasive Developmental Disorder

doi:10.1023/A:1015441428154

Paper

Efficacy of Porcine Secretin in Children with Autism and Pervasive Developmental Disorder

Published Jun 1, 2002 · Janet K. Kern, V. Miller, Patricia A Evans

Journal of Autism and Developmental Disorders

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62

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2

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Abstract

Secretin, a gastrointestinal (GI) hormone, was reported in a preliminary study to improve language and behavior in children with autism/pervasive developmental disorder (PDD) and chronic diarrhea. To determine the efficacy of secretin, we completed a double-blind, placebo-controlled, crossover (3 weeks) study in children with autism/PDD and various GI conditions using a single dose of intravenous porcine secretin. Children with chronic, active diarrhea showed a reduction in aberrant behaviors when treated with the secretin but not when treated with the placebo. Children with no GI problems are unaffected by either secretin or placebo. The improvement seen with secretin in children with autism/PDD and chronic diarrhea suggests that there may be a subtype of children with autism/PDD who respond to secretin.

RCT

Study Snapshot

Porcine secretin improves behavior and language in children with autism/PDD and chronic diarrhea, suggesting a subtype of these children may respond to secretin.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Efficacy of Porcine Secretin in Children with Autism and Pervasive Developmental Disorder

References

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