Paper
Enzymology of long-chain base synthesis by liver: characterization of serine palmitoyltransferase in rat liver microsomes.
Published 1984 · R. D. Williams, E. Wang, A. Merrill
Archives of biochemistry and biophysics
Q1 SJR score
175
Citations
4
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro Study
Highly CitedStudy Snapshot
Serine palmitoyltransferase in rat liver microsomes initiates the synthesis of major long-chain bases and compounds that may constitute unidentified bases in mammalian sphingolipids.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Facile enzymatic synthesis of fatty acylcoenzyme A thioesters.
Fatty acid:CoA ligase immobilized on Matrex Gel Red A is an effective and efficient enzyme for the synthesis of fatty acyl-CoA thioesters, with potential applications in both small-scale and large-scale production.
1982·51citations·A. Merrill et al.·Journal of lipid research
Journal of lipid research
Association and assembly of triglyceride and phospholipid with glycosylated and unglycosylated apoproteins of very low density lipoprotein in the intact liver cell.
Glycosylation of apoprotein B is not necessary for assembly of VLDL glycerolipids or secretion of the VLDL particle in the liver cell.
1982·48citations·P. Siuta-Mangano et al.·The Journal of biological chemistry
The Journal of biological chemistry
Retinol esterification by rat liver microsomes. Evidence for a fatty acyl coenzyme A: retinol acyltransferase.
Retinol esterification in rat liver microsomes is catalyzed by a microsomal acyl-CoA:retinol acyltransferase, with a pool of fatty acyl-CoA available for reaction with [3H]retin
1982·94citations·A. Ross·The Journal of biological chemistry
The Journal of biological chemistry
Regulation of sphingomyelin long chain base synthesis in human fibroblasts in culture. Role of lipoproteins and the low density lipoprotein receptor.
Low density lipoproteins inhibit sphingomyelin long chain base synthesis in human fibroblasts, likely through the low density lipoprotein receptor pathway.
1982·33citations·R. Verdery et al.·The Journal of biological chemistry
The Journal of biological chemistry
A re-examination of some properties of fatty acyl-CoA micelles.
The critical micelle concentration for palmitoyl-CoA is 30 to 60 microM, with an aggregation number near 40 and no larger than 200, contradicting earlier values suggested by Zahler, Barden, and Cleland.
1981·76citations·G. Powell et al.·The Journal of biological chemistry
The Journal of biological chemistry
Citations
Don’t Be Surprised When These Surprise You: Some Infrequently Studied Sphingoid Bases, Metabolites, and Factors That Should Be Kept in Mind During Sphingolipidomic Studies
Infrequently studied sphingoid bases, metabolites, and factors can be overlooked in lipidomic studies, potentially advancing knowledge about their roles in biological processes and diseases.
2025·1citation·Alfred H. Merrill·International Journal of Molecular Sciences
International Journal of Molecular Sciences
Regulated translocation of neutral sphingomyelinase-2 to the plasma membrane drives insulin resistance in steatotic hepatocytes
Neutral sphingomyelinase 2 (nSMase2) regulates ceramide homeostasis in fat-loaded hepatocytes and drives the onset of insulin resistance, with palmitic acid-induced insulin resistance being cell-autonomous and driven by PAL.
2023·4citations·S. El-Amouri et al.·Journal of Lipid Research
Journal of Lipid Research
Serine palmitoyltransferase assembles at ER–mitochondria contact sites
SPTLC2 plays a crucial role in sphingolipid synthesis and protects against palmitate-induced mitochondrial toxicity, providing insights into sphingolipid synthesis and ER-mitochondria contact sites.
2021·19citations·Mari J. Aaltonen et al.·Life Science Alliance
Life Science Alliance
Onset of Senescence and Steatosis in Hepatocytes as a Consequence of a Shift in the Diacylglycerol/Ceramide Balance at the Plasma Membrane
SMS2 regulates diacylglycerol homeostasis and signaling in hepatocytes, and overexpression of SMS2 can drive senescence and steatosis in liver cells through cell-autonomous mechanisms.
2021·4citations·G. Deevska et al.·Cells
Cells
Paradigm shift: the primary function of the “Adiponectin Receptors” is to regulate cell membrane composition
ADIPORs are not just adiponectin receptors, but also regulators of membrane homeostasis, acting as fluidity sensors and promoting fatty acid desaturation and incorporation into phospholipids when membrane rigidity is restored.
2021·21citations·M. Pilon·Lipids in Health and Disease
Lipids in Health and Disease
Heterologous expression of a novel serine palmitoyltransferase from Sphingobium chungbukense
A novel serine palmitoyltransferase gene has been identified in Sphingobium chungbukense, which catalyzes the first rate-limiting reaction in the de novo biosynthesis of sphingolipids.
2021·2citations·H. Um et al.·Toxicology and Environmental Health Sciences
Toxicology and Environmental Health Sciences
Sub-chronic administration of flavonoid fraction Daflon improve lead-induced alterations in delta-aminolevulinic acid dehydratase activity, erythrocytic parameters, and erythrocyte osmotic fragility in Wistar rats
Daflon-enriched foods may be a promising prophylactic agent for individuals living in lead toxicity-prone environments by improving enzyme activity and erythrocytic parameters.
2020·14citations·Ibrahim Yusuf Lamidi et al.·Comparative Clinical Pathology
Comparative Clinical Pathology
Preparation of HeLa Total Membranes and Assay of Lipid-inhibition of Serine Palmitoyltransferase Activity.
This study presents a simple, easy-to-perform assay for measuring serine palmitoyltransferase activity in response to increased sphingolipid levels in mammalian cells.
2020·0citations·M. Kannan et al.·Bio-protocol
Bio-protocol
Sphingolipid Signature of Human Feto-Placental Vasculature in Preeclampsia
Preeclampsia alters the sphingolipid signature and gene expression in the fetal side of the placental vasculature, leading to increased serine palmitoyltransferase activity and impaired endothelial S1P signaling.
2020·37citations·Ilaria Del Gaudio et al.·International Journal of Molecular Sciences
International Journal of Molecular Sciences