Evaluation of some pharmaceutical formulations of lisinopril through dissolution testing.

Paper

Evaluation of some pharmaceutical formulations of lisinopril through dissolution testing.

Published Jul 1, 2010 · Mădălina Vieriu, N. Bibire, M. Apostu

Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi

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Abstract

AIM Lisinopril is a drug of the angiotensin converting enzyme (ACE) inhibitor class that is primarily used in treatment of hypertension, congestive heart failure, heart attacks and also in preventing renal and retinal complications of diabetes. We compared the dissolution profiles of Lisinopril 20 mg tablets (Antibiotice S.A. laşi) and Zestril 20 mg tablets (Astra Zeneca). MATERIAL AND METHOD Because lisinopril is a third class active substance, we performed dissolution tests in standard media at three pH values: 1.2, 4.5 and 6.8 using the paddle apparatus at 75 rpm. RESULTS Both pharmaceutical formulations present a dissolution percentage more than 85% (Q) of the labeled amount. CONCLUSION Both pharmaceutical formulations present similar dissolution profile. Key words:

Study Snapshot

Lisinopril 20 mg tablets (Antibiotice S.A. laşi) and Zestril 20 mg tablets (Astra Zeneca) both have similar dissolution profiles, with over 85% of the labeled amount dissolving in standard media at three pH values.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Evaluation of some pharmaceutical formulations of lisinopril through dissolution testing.

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