Evaluation of safety and efficacy of booster injections of hyaluronic acid in improving the facial skin quality.

doi:10.1111/jocd.13493

Paper

Evaluation of safety and efficacy of booster injections of hyaluronic acid in improving the facial skin quality.

Published May 17, 2020 · A. Ayatollahi, A. Firooz, A. Samadi

Journal of cosmetic dermatology

Q2 SJR score

20

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0

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Abstract

BACKGROUND Skin boosting with small particles of hyaluronic acid (HA) is a new method of skin rejuvenation. AIM Here we aim to evaluate the efficacy and safety of booster injections of non-cross-linked HA in improving the facial skin quality. METHODS 20 men and women age 40.15 ± 6.63 years were treated with 3 injections of non-cross-linked HA (1-2 ml) with intervals of 3 weeks. Skin hydration and elasticity parameters were evaluated before intervention and one week and 4 months later. Facial skin improvement also evaluated using Physician's Global Assessment score (PGA). RESULTS skin hydration increased one week and 4 months after last treatment, (p > 0.05). Skin firmness (R0) reduced significantly at week 1 and month 4 (p-value = 0.01 and 0.00). Skin tiring effect /Fatigue (R3) showed significant decrease at week 1 and month 4 (p-value=0.01 and 0.00 respectively). Four months after last treatment skin gross elasticity (R2) and net elasticity (R5) also increased significantly (p-value=0.00) PGA one week and four months after last treatment were 2.33 ± 0.76 and 1.35± 0.49 out of 4, respectively. Adverse effects were mostly transient and mild in severity. CONCLUSION Booster therapy with HA is a safe and well tolerated procedure and results in improvement in skin elasticity and relative increase in skin hydration.

Non-RCT

Rigorous Journal

Study Snapshot

Key takeawayBooster injections of hyaluronic acid are a safe and well-tolerated procedure that improves skin elasticity and hydration in facial skin.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Evaluation of safety and efficacy of booster injections of hyaluronic acid in improving the facial skin quality.

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References

Citations

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