S. Iwanaga, S. Gokudan, J. Mizuguchi
Journal name not available for this finding
Comparative studies on “fibrinogen-like domains” and von Willebrand factor (vWF) domains found in various proteins have been performed. The “fibrinogen-like domain” is contained in more than 70 functional proteins, which are involved in innate immunity, angiogenesis, development, and differentiation, such as ficolins, tenascins, angiopoietins, and tachylectins. On the other hand, vWF A and D domains are identified extensively in integrins, extracellular matrix proteins, and secreted mucins. These vWF domains, in addition to “fibrinogen-like domains,” are found throughout the vertebrates and in several invertebrate species, indicating that these domains have deep evolutionary roots associated with vertebrate circulatory systems and their roles in homeostasis. These facts suggest that a mechanism of hemostasis is evolutionarily conserved from arthropods to mammals.