Attention deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD) are neurodevelopmental disorders that onset during childhood. They are two of the most common psychiatric disorders affecting pediatric populations. ADHD and OCD share a common sub-phenotype, so it was thought that they may also share common risk alleles. Previously, ADHD and OCD had not been compared on a genome-wide association study (GWAS) or meta-analysis platform. Thus, a GWAS and meta-analysis were conducted for ADHD and OCD. The clinical overlap between the two disorders is also discussed in depth. Further research using larger sample sizes are warranted to increase power.

ADHD and OCD share a common sub-phenotype, suggesting they may share common risk alleles.

Paper

Exploring Polygenic Overlap Between ADHD and OCD

References

Citations