Expression of Id1 in Hepatocellular Carcinomas and Its Correlation with Cell Differentiation
Liu Xiao‐fang
2010
Citations
0
Citations
Quality indicators
Journal
Guide of China Medicine
Semantic Scholar
Key Takeaway Key Takeaway: Id1 protein expression in hepatocellular carcinoma tissues is related to hepatocellular differentiation, suggesting it may play a key role in the earlier occurrence of HCC.
Abstract
Objective To discuss the Id1 protein expression in Chinese hepatocellular carcinoma(HCC)tissues and to analyze its correlation with clinical pathobiology.To study the role of Id1 in the development of HCC.Methods The immunohistochemical method was used to detect Id1 protein expression in 44 cases of hepatocellular carcinoma and adjacent-carcinoma tissues.Linear correlation was analyzed between Id1 expression and Edmondson grade. Results There were strong positive staining of Id1 protein in the adjacent normal tissues and liver cirrhosis.Higher differentiation HCC tissues showed strong or moderate expression,while there was weak or no expression of Id1 protein in the lower differentiation tissues.Statistical analysis showed that expression of Id1 in HCC was inverse correlation to the level of differentiation grade of Edmondson.Conclusion Id1 protein expresses in a higher level among the normal and cirrhosis tissues.The expression of Id1 protein in HCC tissues has relation with the hepatocellular differentiation.The higher differentiation HCC tissues expresses higher Id1 protein comparatively,while lower differentiation HCC tissues has no or weak expression.It suggests that Id1 may play a key role in the earlier occurrence in HCC.