The elimination of monthly withdrawal bleeding with use of extended-cycle (84 pills) monophasic birth-control pills has modernized oral contraceptives. The use of ethinyl estradiol 10 μg pills in place of the seven placebo pills addresses the problems posed by 21/7 formulations of low-dose birth-control pills, which allow early stimulation of ovarian follicles, and of the early 84/7 formulations, which had higher rates of unscheduled bleeding and spotting.

Extended-cycle oral contraceptives with 10 g ethinyl estradiol in place of placebo pills effectively eliminate monthly withdrawal bleeding and address concerns with early stimulation of ovarian follicles and unscheduled bleeding.

Paper

Extended-Cycle Oral Contraceptive Pills with 10 μG Ethinyl Estradiol Pills in Place of Placebo Pills

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