Facile synthesis of 1,4-benzodiazepin-3-ones from o-bromobenzylamines and amino acids via a cascade coupling/condensation process

doi:10.1016/J.TET.2009.06.104

Paper

DOI: 10.1016/J.TET.2009.06.104

Facile synthesis of 1,4-benzodiazepin-3-ones from o-bromobenzylamines and amino acids via a cascade coupling/condensation process

Published Oct 31, 2009 · Hexiang Wang, Yongwen Jiang, Kun Gao

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Abstract

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Study Snapshot

This study demonstrates a facile synthesis of 1,4-benzodiazepin-3-ones from o-bromobenzylamines and amino acids, with moderate yields and enantiopure products when using l-proline and l-valine as starting materials.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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