A flow chemistry Meerwein-Ponndorf-Verley (MPV) reduction procedure using partially hydrated zirconium oxide via a machine-assisted approach is reported. The heterogeneous reductive system could be applied to a wide range of functionalized substrates, allowing clean and fast delivery of the alcohol products within a few minutes (6-75 min). In three examples the system was scaled to deliver 50 mmol of product.

This study presents a mild and efficient flow procedure for transfer hydrogenation of ketones and aldehydes using hydrous zirconia, enabling clean and fast delivery of alcohol products within a few minutes.

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A mild and efficient flow procedure for the transfer hydrogenation of ketones and aldehydes using hydrous zirconia.

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